Carbimazole is associated with an increased risk of congenital malformations when used during pregnancy, especially in the first trimester and at high doses (daily dose of 15 mg or more)
73 m 2 , 1
A European review highlighted continued reports of inadvertent overdose due to more frequent dosing (including daily administration), which has resulted in some fatalities
Hyoscine butylbromide injection is contra-indicated in patients with tachycardia By oromucosal administration using oral gel
For all thiazides and related diuretics
There is a possible small increase in the risk of breast cancer in women using, or who have recently used, progestogen-only contraception
Tri-cyclic anti-depressants
These factsheets have been compiled by our Drugs in Breastmilk information service team of pharmacists
It can occur at any age and is commonly seen in women, the elderly, and during pregnancy
It can be used with caution during breastfeeding, but nifedipine is the preferred dihydropyridine calcium-channel blocker
Compared to nifedipine and other medications in the dihydropyridine class, amlodipine has the longest half-life at 30 to 50 hours
Concomitant diuretics; diabetes (may lower blood glucose; increased risk of hyperkalaemia); first dose hypotension (especially in patients taking high doses of diuretics, on a low-sodium diet, on dialysis, dehydrated, or with cerebrovascular disease, ischaemic heart disease, or heart failure Common or very common
Olmesartan with hydrochlorothiazide
Before treatment initiation risperidone-naïve patients should be titrated with oral risperidone for at least 14 days; patients stabilised on other oral antipsychotics, but with previous response to risperidone, should be titrated with oral