In a patient who has received no theophylline in the previous 24 hours, a loading dose of intravenous theophylline of 4
For the treatment of premature apnea, most clinicians prefer to use caffeine, a related methylxanthine agent, instead of theophylline because of smoother apnea control and Accurate prediction of dose-dependency of theophylline metabolism in patients a priori is not possible, but patients with very high initial clearance rates (i
6 mg/kg (5
Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine
per dose 200 mg), dose may be increased in some children with chronic asthma; increased to 10–16 mg/kg every 12 hours (max
4 mg/kg/day; actual body weight was used unless the ideal body weight was smaller
Theophylline doses greater than 400 mg/d should be prescribed with caution in elderly patients
This review concludes that body weight and age were the most important factors associated with the clearance of theophylline in paediatric patients
Theophylline doses greater than 400 mg/d should be prescribed with caution in elderly patients
9±2